Epidermal remodelling in psoriasis.

Psoriatic hyperproliferative epidermis is characterized by a regular elongation of rete ridges, accompanied by altered keratinization. Another notable finding is close positioning of the vasculature to the suprapapillary epidermis. These architectural/morphological changes are naturally described by a concept of epidermal remodelling based on decreased epidermal turnover time. The recently described positioning of stem cells to the tips of dermal papillae fits nicely with this concept.