Clark B J, Mowat A, Fallowfield M E, Lee F D
University Department of Pathology, Royal Infirmary, Glasgow.
Br J Dermatol. 1996 Sep;135(3):467-70.
Papular mucinosis is a condition reported to be associated with abnormal serum paraproteins and plasma cell dyscrasias. We report a patient with papular mucinosis, without a serum paraprotein or bone marrow plasmacytosis, in whom the affected skin contained a prominent perivascular plasma cell infiltrate. Using in situ hybridization, for kappa and lambda light chain mRNA, these plasma cells were demonstrably monotypic for lambda light chain and, therefore, presumably monoclonal and putatively neoplastic. We suggest that the absence of a serum paraprotein and marrow plasmacytosis does not exclude the existence of a plasma cell neoplasm in patients with papular mucinosis. Such plasma cell populations may exist in the affected skin, although their true nature and behaviour remains to be determined.
丘疹性黏蛋白沉积症据报道与血清副蛋白异常及浆细胞发育异常有关。我们报告了1例丘疹性黏蛋白沉积症患者，其血清中无副蛋白，骨髓中也无浆细胞增多，但其受累皮肤中有显著的血管周围浆细胞浸润。利用原位杂交技术检测κ和λ轻链mRNA，这些浆细胞显示为λ轻链单型性，因此推测为单克隆性且可能是肿瘤性的。我们认为，血清中无副蛋白及骨髓中无浆细胞增多并不能排除丘疹性黏蛋白沉积症患者存在浆细胞瘤。此类浆细胞群体可能存在于受累皮肤中，尽管其真实性质和行为仍有待确定。
