Breteau N, Demasure M, Favre A, Leloup R, Lescrainier J, Sabattier R
CHR Service d'Oncologie et de Radiothérapie, Orléans, France.
Bull Cancer Radiother. 1996;83 Suppl:142s-5s. doi: 10.1016/0924-4212(96)84900-0.
Between 1981 and 1994, 13 patients were referred to the Orleans neutrontherapy department with inoperable or recurrent pelvic chordomas. One patient who had already been irradiated refused the treatment, fearing complications. Among the 12 patients suitable for evaluation, ten had undergone one to five previous surgical operations. The time lapse between the last surgical operation and neutrontherapy was 13 months. Neutrons were used alone or as a boost depending on the tumor volume or treatment purpose. At four years, crude survival and local control probability (Kaplan-Meier) were 61 and 54% respectively. This small series suggests that fast neutrontherapy can provide a good alternative for the treatment of inoperable sacral chordomas.
1981年至1994年间，13例患有无法手术切除或复发性盆腔脊索瘤的患者被转诊至奥尔良中子治疗科。1例已接受过放疗的患者因担心并发症而拒绝治疗。在适合评估的12例患者中，10例曾接受过1至5次手术。最后一次手术与中子治疗之间的时间间隔为13个月。根据肿瘤体积或治疗目的，单独使用中子或作为辅助放疗手段。4年时，总生存率和局部控制率（Kaplan-Meier法）分别为61%和54%。这个小样本系列提示，快中子治疗可为无法手术切除的骶骨脊索瘤提供一种良好的治疗选择。
