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Urinary porphyrins and heme biosynthetic enzyme activities measured by HPLC in arsenic toxicity.

作者信息

García-Vargas G G, Hernández-Zavala A

机构信息

Departo de Farmacología y Toxicología, Centro de Investigación y de Estudios Avanzados del IPN, México D.F., México.

出版信息

Biomed Chromatogr. 1996 Nov-Dec;10(6):278-84. doi: 10.1002/(SICI)1099-0801(199611)10:6<278::AID-BMC613>3.0.CO;2-X.

DOI:10.1002/(SICI)1099-0801(199611)10:6<278::AID-BMC613>3.0.CO;2-X
PMID:8949908
Abstract

Arsenic can modify the urinary excretion of porphyrins in animals and humans. Arsenic also interferes with the activities of several enzymes of the heme biosynthesis pathway, such as aminolevulinate synthase (ALA-S), porphobilinogen deaminase (PBGD), uroporphyrinogen III synthase (Uro III S), uroporphyrinogen decarboxylase (URO-D), coproporphyrinogen oxidase (COPRO-O), ferrochelatase and heme oxygenase (H-O). This review deals with HPLC-based techniques for the analysis of porphyrins in human and rodent urine and several heme enzymes with discussion on their usefulness as early biomarkers of arsenic toxicity.

摘要

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