Emsley R, Smith R, Roberts M, Kapnias S, Pieters H, Maritz S
Department of Psychiatry, University of Stellenbosch, South Africa.
Alcohol Alcohol. 1996 Sep;31(5):479-86. doi: 10.1093/oxfordjournals.alcalc.a008182.
A magnetic resonance imaging study of 19 alcoholic Korsakoff patients, 17 non-amnesic alcoholics and 23 non-alcoholic controls was undertaken. Several measures of ventricular size and interhemispheric area were significantly greater in the Korsakoff patients. Interhemispheric fissure size was greater in the non-amnesic alcoholics than the non-alcoholic controls. Cortical grey matter T1 values were essentially the same for the three groups, whereas the deep grey and the white matter T1 values for the Korsakoff patients were significantly greater than the non-alcoholic controls. These results indicate widespread cerebral atrophy in alcoholic Korsakoff patients, which is largely subcortical and does not develop independently of the diencephalic pathology. Alcoholic dementia may be a more severe form of alcoholic Korsakoff syndrome, aetiologically related to the nutritionally-induced diencephalic pathology, rather than the neurotoxic effects of alcohol on the cortex.
对19名酒精性柯萨科夫综合征患者、17名非遗忘型酗酒者和23名非酗酒对照者进行了磁共振成像研究。柯萨科夫综合征患者的几项脑室大小和半球间面积测量值明显更大。非遗忘型酗酒者的半球间裂大小比非酗酒对照者更大。三组的皮质灰质T1值基本相同，而柯萨科夫综合征患者的深部灰质和白质T1值明显高于非酗酒对照者。这些结果表明，酒精性柯萨科夫综合征患者存在广泛的脑萎缩，主要是皮质下萎缩，且与间脑病变无关。酒精性痴呆可能是酒精性柯萨科夫综合征的一种更严重形式，病因与营养诱导的间脑病变有关，而非酒精对皮质的神经毒性作用有关。
