Hagiwara A, Sakakura C, Tsujimoto H, Ohgaki M, Imanishi T, Yamazaki J, Sawai K, Takahashi T, Yamamoto A, Muranishi S, Tabata Y, Ikada Y
First Department of Surgery, Kyoto Prefectural University of Medicine, Japan.
Anticancer Drugs. 1996 Sep;7(7):780-4. doi: 10.1097/00001813-199609000-00010.
A new dosage formulation of 5-fluorouracil incorporated in microspheres (5-FU-MS) was developed for the treatment of peritoneal carcinomatosis. We studied the acute toxicity and side effects of i.p. 5-FU-MS in mice. The 50% lethal dose value for 5-FU-MS was 535.4 mg/kg of 5-FU, which was 2.22 times that of the aqueous 5-FU solution. Deaths occurred 12-17 days after the administration of 5-FU-MS, but within 11 days after the administration of aqueous 5-FU. Thus, lethal toxicity appeared later with 5-FU-MS than with aqueous 5-FU. There were no differences in pathologic findings on autopsy between mice given the two dosage formulations.
