Upadhyaya K C, Baquer N Z
Hormone and Drug Research Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
Biochem Mol Biol Int. 1996 Nov;40(4):853-60. doi: 10.1080/15216549600201463.
The effects of insulin and the insulin mimetic agent "vanadate" were studied on the activities of alanine aminotransferase, aspartate aminotransferase, glutamate dehydrogenase and arginase in the cytosolic and the mitochondrial fractions of the kidney in control and alloxan induced diabetic rats. An enhancement in the activities of these enzymes were noted in both the fractions of diabetic kidney. Vanadate treatment (0.6 mg/ml in drinking water) of alloxan induced diabetic rats restored the activities of these enzymes almost completely in the cytosolic and partially in the mitochondrial fractions. Vanadate treatment also normalized hyperglycaemia without altering the depressed levels of insulin secretion in diabetic rats. The effect of insulin treatment was found to be the same as that of vanadate in diabetic rats.
研究了胰岛素和胰岛素模拟剂“钒酸盐”对正常大鼠及四氧嘧啶诱导的糖尿病大鼠肾脏胞质和线粒体部分中丙氨酸转氨酶、天冬氨酸转氨酶、谷氨酸脱氢酶和精氨酸酶活性的影响。在糖尿病大鼠肾脏的这两个部分中，均观察到这些酶的活性增强。用钒酸盐（饮用水中浓度为0.6mg/ml）处理四氧嘧啶诱导的糖尿病大鼠，这些酶的活性在胞质部分几乎完全恢复，在线粒体部分部分恢复。钒酸盐处理还使高血糖恢复正常，且未改变糖尿病大鼠胰岛素分泌的降低水平。在糖尿病大鼠中，发现胰岛素治疗的效果与钒酸盐相同。
