儿童急性淋巴细胞白血病中的嗜银性核仁组成区（AgNORs）

Argyrophilic nuclear organizer regions (AgNORs) in pediatric acute lymphoblastic leukemia.

作者信息

Sreelekha T T, Kusumakumary P, Srinivas G, Kumar S R, Pushpakumary S, Nair M K, Pillai M R

机构信息

Division of Laboratory Medicine, Regional Cancer Centre, Thiruvananthapuram, India.

出版信息

Cancer Lett. 1996 Nov 12;108(1):87-91. doi: 10.1016/s0304-3835(96)04397-2.

DOI:10.1016/s0304-3835(96)04397-2

PMID:8950214

Abstract

Nuclear organizer regions (NORs) code for ribosomal RNA and are associated with non-histone nucleoproteins which can be identified by silver staining (AgNORs). AgNORs have been correlated to proliferative activity of tumors and hence may be prognosis-related. The present study evaluates the possible prognostic importance of the AgNORs in tumor cells of patients with pediatric acute lymphoblastic leukemia (ALL). A significant increase in AgNOR counts was observed in ALL patients as compared to normal controls. Further, a significant positive correlation was observed between AgNOR counts and total WBC count at diagnosis. A negative correlation was also observed between AgNOR counts and age of the patients. Logistic regression analysis revealed further correlation between AgNOR counts and disease with an odds ratio of 1.29 (P = 0.03) as compared to normal controls. These results therefore suggest that AgNOR counts may be significant in the evaluation of pediatric ALL.

摘要

核仁组织区（NORs）编码核糖体RNA，并与可通过银染法识别的非组蛋白核蛋白相关（AgNORs）。AgNORs已与肿瘤的增殖活性相关，因此可能与预后有关。本研究评估了AgNORs在小儿急性淋巴细胞白血病（ALL）患者肿瘤细胞中的潜在预后重要性。与正常对照组相比，ALL患者的AgNOR计数显著增加。此外，诊断时AgNOR计数与白细胞总数之间存在显著正相关。AgNOR计数与患者年龄之间也存在负相关。逻辑回归分析显示，与正常对照组相比，AgNOR计数与疾病之间存在进一步的相关性，优势比为1.29（P = 0.03）。因此，这些结果表明AgNOR计数在小儿ALL的评估中可能具有重要意义。