Ashraf M S, Skinner R, English M W, Craft A W, Pearson A D
Sir James Spence Institute of Child Health, Royal Victoria Infirmary, Newcastle upon Tyne, England.
Med Pediatr Oncol. 1997 Jan;28(1):62-4. doi: 10.1002/(sici)1096-911x(199701)28:1<62::aid-mpo12>3.0.co;2-c.
Although reversibility of acute ifosfamide-induced nephrotoxicity is well documented, there is a paucity of data concerning the long-term outcome of chronic renal toxicity, and full recovery from established damage has not been reported. A 4-year-old boy presented with hypophosphatemic rickets 9 months after completion of combination chemotherapy (including ifosfamide) for prostatic rhabdomyosarcoma. Further investigation confirmed glomerular and generalised tubular dysfunction with a Fanconi syndrome. However, serial investigation over the next 4 years revealed complete and sustained recovery of this chronic nephrotoxicity.
虽然急性异环磷酰胺诱导的肾毒性的可逆性已有充分记录，但关于慢性肾毒性的长期后果的数据却很少，而且尚未有已确立损伤完全恢复的报道。一名4岁男孩在完成针对前列腺横纹肌肉瘤的联合化疗（包括异环磷酰胺）9个月后出现低磷性佝偻病。进一步检查证实存在肾小球及全身性肾小管功能障碍，并伴有范科尼综合征。然而，在接下来的4年里进行的系列检查显示，这种慢性肾毒性完全且持续恢复。
