Taton G, Ghanem G, Pandin P, Goldzarian J, Thaysse C, Bertin L, Ickx B, Medhi A, Salari A, Vanherweghem J L, Lambilliotte J P
Department of Gastrointestinal Surgery Surgical Oncology, Hôpital Erasme, Brussels, Belgium.
Acta Chir Belg. 1996 Sep-Oct;96(5):206-10.
Intra-arterial chemotherapy combined with haemofiltration enables the administration of drugs to confined neoplastic tissue while limiting the systemic drug exposure. During the procedure, the cytotoxic drugs are injected into the arterial supply of the tumour and the venous blood coming from the tumour bed is pumped out and filtered trough haemofiltration unit in order to extract the cytotoxic drug not fixed on the tumour. The patients selected for such treatment failed previous intravenous chemotherapy. Thirteen patients underwent intra-arterial chemotherapy injections combined with haemofiltration procedures: 8 unresectable liver metastases from colorectal cancer and 5 pelvic recurrences from rectal cancer. Fluorouracil, mitomycin C and doxorubicin were infused. One out of thirteen patients presented a complete regression of his liver metastases, 5/13 presented a partial regression, 2/13 patients did not show any significant modification of the size of their lesions and were classified as stable disease, 5/13 patients showed a progression of their neoplastic disease. No nephrotoxicity or major gastrointestinal side effects were observed. Intra-arterial chemotherapy combined with haemofiltration procedure is a therapeutic modality that could be considered in patients with locally advanced cancer who failed previous first line intravenous chemotherapy.
动脉内化疗联合血液滤过能够将药物输送至局限的肿瘤组织，同时限制全身药物暴露。在该过程中，将细胞毒性药物注入肿瘤的动脉供血中，并将来自肿瘤床的静脉血泵出，通过血液滤过装置进行过滤，以提取未固定在肿瘤上的细胞毒性药物。选择接受这种治疗的患者先前静脉化疗失败。13例患者接受了动脉内化疗注射联合血液滤过程序：8例为结直肠癌不可切除的肝转移，5例为直肠癌盆腔复发。输注了氟尿嘧啶、丝裂霉素C和阿霉素。13例患者中有1例肝转移完全消退，5/13例部分消退，2/13例患者病变大小无明显变化，归类为疾病稳定，5/13例患者肿瘤疾病进展。未观察到肾毒性或严重的胃肠道副作用。动脉内化疗联合血液滤过程序是一种治疗方式，对于先前一线静脉化疗失败的局部晚期癌症患者可考虑采用。
