Smith A B, Peterson P, Wieland J, Moriarty T, DeLisi L E
Department of Psychiatry, SUNY at Stony Brook, NY 11794, USA.
Am J Med Genet. 1996 Nov 22;67(6):560-3. doi: 10.1002/(SICI)1096-8628(19961122)67:6<560::AID-AJMG9>3.0.CO;2-L.
In the course of recruiting families with 2 schizophrenic siblings for genome screening and linkage studies, a family was found with mental retardation, schizophrenia, and/or other related psychotic illnesses in individuals who also had an unbalanced or balanced translocation between chromosomes 21-18 [t(18;21)(p11.1;p11.1)]. The pericentric region of chromosome 18 has already been noted as a possible location of a gene for bipolar psychosis. The family described here provides further evidence that this region should be examined for a candidate psychosis gene.
在招募有两名精神分裂症同胞的家庭进行基因组筛查和连锁研究的过程中，发现了一个家庭，其中一些个体患有智力迟钝、精神分裂症和/或其他相关精神疾病，这些个体在21号和18号染色体之间还存在不平衡或平衡易位[t(18;21)(p11.1;p11.1)]。18号染色体的着丝粒周围区域已被指出可能是双相情感障碍基因的一个位置。这里描述的这个家庭提供了进一步的证据，表明应该对该区域进行候选精神疾病基因的检测。
