Yamaguchi H, Ikemoto H, Watanabe K, Ito A, Hara K, Kohno S
Teikyo University Research Center for Medical Mycology, Japan.
Eur J Clin Microbiol Infect Dis. 1996 Oct;15(10):787-92. doi: 10.1007/BF01701520.
Treatment with 200 to 400 mg/day fluconazole was evaluated in 44 patients without AIDS who had cryptococcosis (19 with cryptococcal meningitis, 22 with pulmonary cryptococcosis, 3 with other cryptococcal infections). For all patients, the clinical response rate was 89% (48% were clinically cured and 41% clinically improved). Of the patients with cryptococcal meningitis, 89% were mycologically cured. These rates are comparable to those obtained in the treatment of AIDS patients with cryptococcal disease. In the group of patients with cryptococcal meningitis, there was a high rate of agreement between the mycological response to therapy and cryptococcal antigen test results. The use of cryptococcal antigen testing is recommended in all patients with cryptococcosis.
对44例无艾滋病的隐球菌病患者（19例患有隐球菌性脑膜炎，22例患有肺隐球菌病，3例患有其他隐球菌感染）进行了每日200至400毫克氟康唑的治疗评估。所有患者的临床缓解率为89%（48%临床治愈，41%临床改善）。患有隐球菌性脑膜炎的患者中，89%真菌学治愈。这些比率与艾滋病合并隐球菌病患者治疗中获得的比率相当。在隐球菌性脑膜炎患者组中，治疗的真菌学反应与隐球菌抗原检测结果之间的一致性很高。建议对所有隐球菌病患者进行隐球菌抗原检测。
