Nirmala V, Chacko C J, Job C K
Lepr India. 1977 Jan;49(1):65-9.
Since it has been found hard to differentiate histopathologically tuberculoid leprosy from tuberculosis of the skin, a study of 20 biopsies from each of those conditions was undertaken to identify if possible some of their characteristic features. In tuberculoid leprosy along with tuberculoid granulomata there is always selective involvement and destruction of nerves, lack of fibrosis, absence of caseous necrosis and often epidermal atrophy. In cutaneous tuberculosis, on the other hand, in addition to tuberculous granuloma, there is often a proliferation reaction of the epidermis, areas of ulceration, absence of nerve destruction, marked increase in the reticulin, significant fibrosis and occasionally caseous necrosis.
由于已发现从组织病理学上难以区分结核样型麻风与皮肤结核，因此对这两种病症各取20份活检样本进行研究，以尽可能确定它们的一些特征。在结核样型麻风患者中，除了结核样肉芽肿外，总是存在神经的选择性受累和破坏、缺乏纤维化、无干酪样坏死且常伴有表皮萎缩。另一方面，在皮肤结核中，除了结核肉芽肿外，表皮常有增生反应、溃疡区域、无神经破坏、网硬蛋白显著增加、明显纤维化且偶尔有干酪样坏死。
