Mita S, Matsuura T, Adachi M
First Department of Internal Medicine, Showa University.
Nihon Rinsho. 1996 Nov;54(11):2898-902.
Airway inflammation is a feature of bronchial asthma and can be quantified invasively with bronchial mucosal biopsy and bronchoalveolar lavage. The induction of sputum by the inhalation of hypertonic saline however is safer and more noninvasive when compared with such methods. Evidence of airway inflammation may be revealed by examining hypertonic saline-induced sputum for eosinophils, cytokines and eosinophil cationic protein. There is a clear need however to develop further noninvasive discriminant measurement of airway inflammation.
气道炎症是支气管哮喘的一个特征，可以通过支气管黏膜活检和支气管肺泡灌洗进行有创量化。然而，与这些方法相比，吸入高渗盐水诱导痰液更安全、更无创。通过检查高渗盐水诱导痰液中的嗜酸性粒细胞、细胞因子和嗜酸性粒细胞阳离子蛋白，可能会发现气道炎症的证据。然而，显然需要进一步开发无创的气道炎症判别测量方法。
