Gaynes B I, Fiscella R G
Department of Pharmacy Practice, University of Illinois at Chicago College of Pharmacy, USA.
J Ocul Pharmacol Ther. 1996 Winter;12(4):527-39. doi: 10.1089/jop.1996.12.527.
The purpose of this paper is to review the biochemical processes of systemic biotransformation and describe their relevance to ocular disease and drug metabolism. The diverse nature of the biochemical pathways, commonly found in enzyme metabolism, is discussed. The occurrence of these processes in the eye has significance in that the products of metabolism may accumulate locally and exert deterimental effects, presumably by altering the cellular structure and/or function of crucial visual elements. The manipulation of these metabolic pathways within the eye has ramifications in the development of novel drug design for both ocular disease treatment and, perhaps more importantly, disease prevention.
本文的目的是回顾全身生物转化的生化过程，并描述它们与眼部疾病和药物代谢的相关性。文中讨论了酶代谢中常见的生化途径的多样性。这些过程在眼部的发生具有重要意义，因为代谢产物可能在局部积累并产生有害影响，推测是通过改变关键视觉元件的细胞结构和/或功能。在眼内对这些代谢途径进行调控，对于开发用于眼部疾病治疗以及或许更重要的疾病预防的新型药物设计具有影响。
