Ghanem R, Bello M A, Callejón M, Guiraúm A
Department of Analytical Chemistry, Faculty of Chemistry, University of Seville, Spain.
J Pharm Biomed Anal. 1996 Dec;15(3):383-8. doi: 10.1016/s0731-7085(96)01864-x.
A rapid and feasible chromatographic method for determining atenolol, metoprolol, alprenolol, oxprenolol, acebutolol and propranolol by non-suppressed ion chromatography is proposed. The mobile phase consisted of 50 mM nitric acid in an aqueous solution of 4% (v/v) acetonitrile. Detection limits are in the range 0.1-2.7 mg l-1. The method was successfully applied to the determination of beta-blockers in several pharmaceutical formulations.
