Ricci A, Kourea H P, Wortyla S
Department of Pathology, Hartford Hospital, USA.
Conn Med. 1996 Oct;60(10):587-90.
Fibroadenomas (FA) are benign neoplasms with a known albeit rare association with mammary carcinoma (MC). Incompletely explored, however, are 1) the statistical relationship of associated FA/MC with patient age and 2) the microscopic spatial relationship of associated FA/ MC. Pathology records of 1,715 patients with FA, excised over a nine-year period, were reviewed. In 59 patients concomitant diagnoses of FA and MC were rendered. In 40 of these patients MC was clinically unsuspected, signs and symptoms being attributable to the FA. Data were age stratified and slides were reviewed to identify the precise histologic association of FA and MC. Women aged 50 years and older had a statistically significant increased association of FA and MC as compared to their younger counterparts (4.1% vs 1.5%; P = .003). MC complicating FA was in situ or invasive (82.5% vs 17.5%), of ductal, lobular, or combined type (40% vs 52.5% vs 7.5%), and half of the MC were restricted to the "normal" mammary tissue surrounding the FA.
纤维腺瘤（FA）是一种良性肿瘤，与乳腺癌（MC）存在已知但罕见的关联。然而，尚未充分探讨的是：1）相关FA/MC与患者年龄的统计关系；2）相关FA/MC的微观空间关系。回顾了在九年期间切除的1715例FA患者的病理记录。其中59例患者同时诊断出FA和MC。在这些患者中，40例患者的MC在临床上未被怀疑，体征和症状归因于FA。对数据进行年龄分层，并对切片进行复查，以确定FA和MC的确切组织学关联。与年轻女性相比，50岁及以上女性的FA和MC关联在统计学上显著增加（4.1%对1.5%；P = 0.003）。并发FA的MC为原位癌或浸润癌（82.5%对17.5%），为导管型、小叶型或混合型（40%对52.5%对7.5%），且一半的MC局限于FA周围的“正常”乳腺组织。
