Roberts L, Balkaran B N, Asgarali Z, Mohammed W, Khan-Hosein J
Department of Child Health, University of the West Indies.
West Indian Med J. 1996 Sep;45(3):92-4.
57 children with idiopathic nephrotic syndrome who were seen at two hospitals in Trinidad between 1989 and 1995 (median follow-up period, 38 months) were classified according to their response to glucocorticoids. 27 (47%) were two to six years old at presentation; 37 (65%) were of East Indian descent, 7 (12%) were of African descent, and 12 (21%) were of mixed race. 55 (96%) responded to glucocorticoids. Renal biopsies in 15 patients revealed membranoproliferative glomerulonephritis and membranous nephropathy in the two patients who had not responded to glucocorticoids. Ten patients showed mesangial hypercellularity, associated with immunoglobulin deposits in 7 cases. Age, presentation with nephrotic features, mesangial hypercellularity and immunoglobulin deposits did not predict for unresponsiveness to glucocorticoids. These findings may be explained by the predominance of East Indians in the study group.
1989年至1995年期间，在特立尼达的两家医院就诊的57例特发性肾病综合征患儿（中位随访期为38个月），根据其对糖皮质激素的反应进行分类。27例（47%）初诊时年龄为2至6岁；37例（65%）为东印度裔，7例（12%）为非洲裔，12例（21%）为混血儿。55例（96%）对糖皮质激素有反应。15例患者的肾活检显示，未对糖皮质激素产生反应的2例患者为膜增生性肾小球肾炎和膜性肾病。10例患者表现为系膜细胞增多，其中7例伴有免疫球蛋白沉积。年龄、肾病特征表现、系膜细胞增多和免疫球蛋白沉积均不能预测对糖皮质激素无反应。这些发现可能是由于研究组中东印度人占多数所致。
