Marchesi E, Martignoni A, Salvini M, Catalano O, Maggi E, Negro C, Traversa B, Bellomo G
Department of Internal Medicine and Medical Therapeutics, University of Pavia, Italy.
J Hum Hypertens. 1996 Sep;10(9):577-82.
Low density lipoproteins (LDL) from hypertensive patients are more prone to in vitro oxidation and undergo a more pronounced oxidation in vivo. Due to the pro-atherogenic activity of oxidatively modified LDL, the correlation between the carotid intima-media thickening (IMT) and the markers of in vivo LDL oxidation was investigated in hypertensive patients. A cross-sectional study on 101 normocholesterolemic patients with newly diagnosed and untreated essential hypertension was performed. The occurrence of in vivo LDL oxidation was evaluated by measuring the titers of autoantibodies against Cu(2+)-oxidised LDL (oxLDL) and malondialdehyde-derivatised LDL (MDA-LDL). The extent and degree of atherosclerosis and the IMT were measured by means of carotid and femoral ultrasonography with a duplex scanner equipped with a high resolution probe. We did not find significant correlations between in vivo LDL oxidation parameters and the extent of atherosclerotic lesion in the entire group of hypertensive patients. However, a significant direct correlation was detected between the carotid IMT and the titer of autoantibodies against both oxLDL and MDA-LDL in hypertensive patients without advanced atherosclerotic plaques. The results obtained support the hypothesis that enhanced LDL oxidation may be one of the pathophysiological events related to the formation and progression of early atherosclerotic lesions (IMT) in carotid arteries of hypertensive patients.
高血压患者的低密度脂蛋白（LDL）在体外更易发生氧化，且在体内氧化更为显著。由于氧化修饰的LDL具有促动脉粥样硬化活性，因此在高血压患者中研究了颈动脉内膜中层增厚（IMT）与体内LDL氧化标志物之间的相关性。对101例新诊断且未经治疗的原发性高血压正常胆固醇血症患者进行了一项横断面研究。通过测量针对铜（2+）氧化LDL（oxLDL）和丙二醛衍生LDL（MDA-LDL）的自身抗体滴度来评估体内LDL氧化的发生情况。使用配备高分辨率探头的双功能扫描仪，通过颈动脉和股动脉超声检查来测量动脉粥样硬化的程度和IMT。在整个高血压患者组中，我们未发现体内LDL氧化参数与动脉粥样硬化病变程度之间存在显著相关性。然而，在无晚期动脉粥样硬化斑块的高血压患者中，检测到颈动脉IMT与针对oxLDL和MDA-LDL的自身抗体滴度之间存在显著的直接相关性。所获得的结果支持以下假设：增强的LDL氧化可能是与高血压患者颈动脉早期动脉粥样硬化病变（IMT）的形成和进展相关的病理生理事件之一。
