Carlsson R M, Claesson B A, Lagergård T, Käyhty H
Department of Infectious Diseases, Göteborg University, Sweden.
Scand J Infect Dis. 1996;28(5):519-23. doi: 10.3109/00365549609037951.
In 1990-91 we compared 2 Haemophilus influenzae type b (Hib) conjugate vaccines and 2 different regimens of tetanus vaccination, by vaccinating 142 Swedish infants at ages 3, 5, and 12 months, with either PRP-T (the capsular polysaccharide of Hib conjugated to tetanus toxoid) + D (diphtheria toxoid), or with PRP-OMP (PRP conjugated to an outer membrane complex of meningococcus group B) + DT (diphtheria-tetanus toxoid). In this follow-up, antibodies against Hib and tetanus were analyzed in sera from 133 of the children at the age of 2.5 years. Hib antibodies (> or = 0.06 micrograms/ml) were found in 99% of the children of both groups, but 93% of the PRP-T vaccinees had maintained Hib antibodies > or = 0.15 micrograms/ml, as compared with 80% of the PRP-OMP vaccinees (p < 0.05). In 1992, the batch of PRP-OMP was reported to have questionable immunogenicity. Tetanus toxoid (T) antibodies (> or = 0.01 IU/ml) were found in all sera from both groups. All sera with T antibodies < 0.1 IU/ml showed tetanus toxin neutralizing activity. However, only 75% of children vaccinated with PRP-T had T antibodies > or = 0.1 IU/ml, as compared to 97% of children vaccinated with DT (p < 0.001). In conclusion, Hib and tetanus antibodies were well maintained 18 months after primary vaccination, also in the group vaccinated with the batch of PRP-OMP of somewhat low immunogenicity and in the group of infants receiving their primary tetanus vaccination only by the carrier protein of PRP-T.
1990 - 1991年，我们对两种b型流感嗜血杆菌（Hib）结合疫苗和两种不同的破伤风疫苗接种方案进行了比较。我们给142名瑞典婴儿在3、5和12月龄时接种疫苗，接种的疫苗分别为PRP-T（Hib的荚膜多糖与破伤风类毒素结合物）+ D（白喉类毒素），或者PRP-OMP（PRP与B群脑膜炎球菌外膜复合物结合物）+ DT（白喉 - 破伤风类毒素）。在此次随访中，对133名2.5岁儿童的血清进行了Hib和破伤风抗体分析。两组中99%的儿童检测到Hib抗体（≥0.06微克/毫升），但PRP-T疫苗接种组中93%的儿童Hib抗体维持在≥0.15微克/毫升，而PRP-OMP疫苗接种组这一比例为80%（p<0.05）。1992年，有报告称PRP-OMP批次的免疫原性存疑。两组所有血清中均检测到破伤风类毒素（T）抗体（≥0.01国际单位/毫升）。所有T抗体<0.1国际单位/毫升的血清均显示出破伤风毒素中和活性。然而，PRP-T疫苗接种组中只有75%的儿童T抗体≥0.1国际单位/毫升，而DT疫苗接种组这一比例为97%（p<0.001）。总之，在初次接种疫苗18个月后，Hib和破伤风抗体维持良好，这在接种了免疫原性略低的PRP-OMP批次疫苗的组以及仅通过PRP-T的载体蛋白进行初次破伤风疫苗接种的婴儿组中均如此。
