Komatsu H, Enzan K
Department of Anesthesiology, Hiraka General Hospital, Yokote.
Masui. 1996 Nov;45(11):1319-22.
Protamine may act on endothelial cell receptors to stimulate the production of nitric oxide, which would promote vasodilation. If so, the repeated administration of protamine may attenuate protamine-induced systemic hypotension. To confirm this hypothesis, we examined whether repeated administration of protamine attenuates protamine-induced systemic hypotension in rats. Rats were divided into two groups. In bolus injection group (S group), protamine was given intravenously at 10 mg.kg-1. In repeated administered group (R group), the same dose of protamine was given intravenously 30 min after continuous infusion of protamine 10 mg.kg-1. The mean arterial pressure in S group decreased significantly after administration of protamine, compared with R group. Also, maximal decrease rate of the arterial pressure after administration of protamine in R group was significantly lower than in S group. These results demonstrate that repeated administration of protamine attenuates protamine-induced systemic hypotension. We confirm the hypothesis that protamine will release nitric oxide by binding with the receptor on the endothelium in the vessel and subsequently cause systemic hypotension.
鱼精蛋白可能作用于内皮细胞受体，刺激一氧化氮的产生，从而促进血管舒张。如果是这样，重复给予鱼精蛋白可能会减轻鱼精蛋白引起的全身性低血压。为了证实这一假设，我们研究了重复给予鱼精蛋白是否能减轻大鼠中鱼精蛋白引起的全身性低血压。将大鼠分为两组。在单次注射组（S组）中，以10mg·kg-1的剂量静脉注射鱼精蛋白。在重复给药组（R组）中，在连续输注10mg·kg-1鱼精蛋白30分钟后，静脉给予相同剂量的鱼精蛋白。与R组相比，S组给予鱼精蛋白后平均动脉压显著降低。此外，R组给予鱼精蛋白后动脉压的最大下降率显著低于S组。这些结果表明，重复给予鱼精蛋白可减轻鱼精蛋白引起的全身性低血压。我们证实了这一假设，即鱼精蛋白通过与血管内皮上的受体结合释放一氧化氮，随后导致全身性低血压。
