替勃龙酸对大鼠肝脏胆固醇合成的影响。
Effect of tibric acid on hepatic cholesterol synthesis in rats.
作者信息
Cayen M N, Dubuc J, Dvornik D
出版信息
Lipids. 1977 Aug;12(8):684-8. doi: 10.1007/BF02533766.
PMID:895418
Abstract
Male albino rats were administered various oral doses of tibric acid daily for 1 week. Serum cholesterol and triglyceride levels were reduced, but total liver content of cholesterol, phospholipids, and triglycerides was increased. Tibric acid treatment suppressed the incorporation of both [14C] acetate and [3H] mevalonate into cholesterol by liver homogenates.
摘要
雄性白化大鼠每天口服不同剂量的替贝酸，持续1周。血清胆固醇和甘油三酯水平降低，但肝脏中胆固醇、磷脂和甘油三酯的总含量增加。替贝酸处理抑制了肝匀浆将[14C]乙酸盐和[3H]甲羟戊酸掺入胆固醇的过程。
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