Martin S J, Corrado O J, Kay E A
J Wound Care. 1996 Jul;5(7):310-1. doi: 10.12968/jowc.1996.5.7.310.
In a randomised, double-blind, controlled trial, a comparison was made of the relative efficacy of using streptokinase/streptodornase (Varidase) in a hydrogel (KY Jelly) or the hydrogel alone in the debridement of Grade IV pressure sores. Seventeen subjects aged 57-94 years (mean age 81) took part; 21 sores were studied, 11 of which were randomised to the enzyme treatment regime. Both treatments led to eschar removal; fewer days were needed in the hydrogel-only group (mean 8.1 days, sd 1.8) compared to the enzyme/hydrogel group (mean 11.8 days, sd 2.9), but this was not statistically significant. The results suggest that the use of hydrogel alone may be a cost-effective alternative to the use of streptokinase/streptodornase and hydrogel in the treatment of these wounds.
在一项随机、双盲、对照试验中，比较了在水凝胶（KY胶）中使用链激酶/链道酶（Varidase）或单独使用水凝胶对IV期压疮进行清创的相对疗效。17名年龄在57 - 94岁（平均年龄81岁）的受试者参与；研究了21处溃疡，其中11处随机分配至酶治疗方案组。两种治疗均导致焦痂清除；仅用水凝胶组（平均8.1天，标准差1.8）相比酶/水凝胶组（平均11.8天，标准差2.9）所需天数更少，但差异无统计学意义。结果表明，在治疗这些伤口时，单独使用水凝胶可能是使用链激酶/链道酶和水凝胶的一种具有成本效益的替代方法。
