Randala M, Eronen M, Andersson S, Pohjavuori M, Pesonen E
Department of Paediatrics, University Hospital of Tartu, Estonia.
Acta Paediatr. 1996 Nov;85(11):1344-7. doi: 10.1111/j.1651-2227.1996.tb13922.x.
Systolic pulmonary artery pressure (PAP) during the first 4 days after birth was determined in 41 healthy term and 46 preterm infants by measuring ductal Doppler flow velocity and systemic arterial pressure (SAP). Among preterm infants, 21 had respiratory distress syndrome (RDS) and 25 did not. Sequential indices within 96 h of age were presented respectively. At the ages of 2 and 12 h the ratio between pulmonary and systemic arterial pressure was significantly higher in term than in preterm infants without RDS (p < 0.05). At the age of 24 h, PAP to SAP ratio was similar in all study groups. Between 48 and 72 h, PAP to SAP ratio was significantly higher in preterm infants with RDS than in infants without RDS (p < 0.05). Our findings indicated that: (1) in healthy fullterm infants pulmonary artery pressure fell to subsystemic level during the first 12 h, indicating the critical time in circulatory transition; (2) prematurity did not affect ductal closure times significantly; and (3) RDS was associated with prolonged ductal patency and delayed postnatal circulatory adaptation characterized by pulmonary hypertension.
通过测量动脉导管多普勒流速和体循环动脉压（SAP），对41例足月健康婴儿和46例早产婴儿出生后前4天的收缩期肺动脉压（PAP）进行了测定。在早产婴儿中，21例患有呼吸窘迫综合征（RDS），25例未患。分别给出了96小时内的连续指标。在2小时和12小时时，足月婴儿的肺动脉压与体循环动脉压之比显著高于无RDS的早产婴儿（p<0.05）。在24小时时，所有研究组的PAP与SAP之比相似。在48至72小时之间，患有RDS的早产婴儿的PAP与SAP之比显著高于未患RDS的婴儿（p<0.05）。我们的研究结果表明：（1）在健康足月婴儿中，肺动脉压在出生后前12小时降至低于体循环水平，这表明是循环转变的关键时期；（2）早产对动脉导管关闭时间没有显著影响；（3）RDS与动脉导管持续开放时间延长以及以肺动脉高压为特征的出生后循环适应延迟有关。
