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乳腺癌的定量DNA倍体分析:联合摄影专家组(JPEG)压缩对DNA倍体图像影响的研究

Quantitative DNA ploidy analysis of breast carcinoma: a study of the effects of joint photographer experts group (JPEG) compression on DNA ploidy images.

作者信息

Phillips L A, Phillips K L, Gahm T, Lai-Goldman M, Needham L B, Wray B E, Macri T F

机构信息

Roche Image Analysis Systems, Inc., Elon College, NC 27244, USA.

出版信息

Diagn Cytopathol. 1996 Sep;15(3):231-6. doi: 10.1002/(SICI)1097-0339(199609)15:3<231::AID-DC11>3.0.CO;2-H.

DOI:10.1002/(SICI)1097-0339(199609)15:3<231::AID-DC11>3.0.CO;2-H
PMID:8955607
Abstract

Telepathology usage in the past has typically been a qualitative procedure rather than a quantitative measurement. DNA ploidy using image analysis has been favorably compared to DNA ploidy analysis by flow cytometry in numerous publications. A step from DNA ploidy analysis using conventional image analysis to DNA ploidy analysis using stored images allows DNA ploidy analysis by image cytometry to become a powerful tool in telepathology. Remote DNA ploidy analysis using stored images has an impact on the field of pathology, as not every hospital or laboratory can afford to perform this type of specialized testing. However, images have large data files and require lengthy transmission times over communication systems to other computers. Joint Photographer Experts Group (JPEG) compression is a computer algorithm that allows the file size of an image to be reduced in order to decrease transmission times to another computer. A study was initiated to investigate the effects of JPEG compression on images of Feulgen stained breast tumor touch preps and the resulting DNA ploidy histograms.

摘要

过去,远程病理学的应用通常是一种定性程序,而非定量测量。在众多出版物中,使用图像分析的DNA倍体分析已被证明与流式细胞术的DNA倍体分析效果相当。从使用传统图像分析的DNA倍体分析迈向使用存储图像的DNA倍体分析,使得图像细胞术的DNA倍体分析成为远程病理学中的一项强大工具。使用存储图像进行远程DNA倍体分析对病理学领域产生了影响,因为并非每个医院或实验室都有能力进行此类专业检测。然而,图像具有大型数据文件,并且通过通信系统传输到其他计算机需要很长时间。联合图像专家组(JPEG)压缩是一种计算机算法,可减小图像的文件大小,以减少传输到另一台计算机的时间。一项研究旨在调查JPEG压缩对福尔根染色的乳腺肿瘤触摸涂片图像以及由此产生的DNA倍体直方图的影响。

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