Geary C G, Benn R T, Leck I
Lancet. 1979 Sep 15;2(8142):549-51. doi: 10.1016/s0140-6736(79)91613-1.
Identification of a "cluster" of cases of acute myeloid leukaemia and chronic myeloproliferative disorders in Lytham St. Annes, Lancashire, prompted an analysis of the incidence of myeloid leukaemias in Lancashire (excluding Ormskirk Health District), as recorded by the Manchester Cancer Registry. Although statistically there was no significant difference in the trend of incidence between the whole former borough of Lytham St. Annes and the other districts studied, the reported incidence of these diseases in the area as a whole had almost doubled, and in two districts nearly trebled, between two consecutive 6 year periods, beginning in 1965. This represents a substantially larger increase than mortality data suggests has occurred nationally in the same period, and is unlikely to be due solely to more accurate diagnosis or reporting.
兰开夏郡利瑟姆圣安妮斯出现的急性髓细胞白血病和慢性骨髓增殖性疾病“病例群”促使人们对曼彻斯特癌症登记处记录的兰开夏郡（不包括奥姆斯柯克健康区）髓细胞白血病的发病率进行分析。尽管从统计学角度来看，整个利瑟姆圣安妮斯前自治市镇与其他研究地区之间的发病率趋势没有显著差异，但在始于1965年的两个连续6年期间，该地区这些疾病的报告发病率几乎翻了一番，在两个地区几乎增长了两倍。这一增长幅度远高于同期全国死亡率数据所显示的增长幅度，不太可能仅仅是由于诊断或报告更加准确所致。
