健康人体中循环心房利钠肽与血清钠和氯之间的昼夜节律关系。

Circadian relationships between circulating atrial natriuretic peptides and serum sodium and chloride in healthy humans.

作者信息

Sothern R B, Vesely D L, Kanabrocki E L, Bremner F W, Third J L, McCormick J B, Dawson S, Ryan M, Greco J, Bean J T, Nemchausky B M, Shirazi P, Scheving L E

机构信息

Rhythmometry Laboratory, St. Paul-Ramsey Medical Center, Minneapolis, Minn, USA.

出版信息

Am J Nephrol. 1996;16(6):462-70. doi: 10.1159/000169045.

DOI:10.1159/000169045

PMID:8955756

Abstract

Long-acting natriuretic peptide (LANP), vessel dilator (VSDL), and atrial natriuretic factor (ANF) consisting of amino acids 1-30, 31-67, and 99-126 of the 126 amino acid ANF prohormone, respectively, circulate in humans and have potent natriuretic properties. To determine whether these peptides have a direct relationship to serum Na and/or Cl, we examined 21 24-hour profiles of these peptides and Na and Cl in 14 healthy humans. LANP, VSDL, ANF, and Cl had significant (p < 0.001) circadian rhythms with peak concentrations at 04.00 h. The circadian rhythm of serum Na was exactly opposite. Sodium correlated negatively with LANP (p = 0.021) and ANF (p = 0.007), while Cl correlated positively with LANP (p = 0.003) and VSDL (p = 0.001). These data suggest that the atrial peptides may be important for the maintenance of serum Na and Cl within their normal ranges and in the modulation of their daily circadian rhythms.

摘要

长效利钠肽（LANP）、血管扩张剂（VSDL）和心房利钠因子（ANF）分别由126个氨基酸的ANF前体激素的第1 - 30、31 - 67和99 - 126位氨基酸组成，它们在人体中循环并具有强大的利钠特性。为了确定这些肽是否与血清钠和/或氯有直接关系，我们检测了14名健康人的这三种肽以及钠和氯的21个24小时变化曲线。LANP、VSDL、ANF和氯具有显著（p < 0.001）的昼夜节律，峰值浓度出现在04:00。血清钠的昼夜节律则正好相反。钠与LANP（p = 0.021）和ANF（p = 0.007）呈负相关，而氯与LANP（p = 0.003）和VSDL（p = 0.001）呈正相关。这些数据表明，心房肽可能对于将血清钠和氯维持在正常范围内以及调节它们的每日昼夜节律很重要。