Synthesis and activity of pseudotripeptide inhibitors of HIV-1 protease containing D(-)-O-(benzyl)tartaric acid.
作者信息
Marastoni M, Fantin G, Bortolotti F, Tomatis R
机构信息
Department of Pharmaceutical Science, University of Ferrara, Italy.
出版信息
Arzneimittelforschung. 1996 Nov;46(11):1099-101.
PMID:8955873
Abstract
Four HIV-1 protease inhibitors containing [(S,S)-O-(benzyl) tartaric acid]-Pro as a transition-state mimic were prepared and evaluated by a spectrophotometric assay. Two pseudotripeptide derivatives showed weak inhibitory activity similar to acetylpepstatin.
摘要
Zotero 插件