Unger F, Deutsch M, Eckersberger F, Losert U, Stellwag F, Thoma H, Wolner E, Polzer K, Navratil J
Med Instrum. 1977 Jul-Aug;11(4):208-11.
Thrombi formation within artificial ventricles is caused by the effects of biomaterials, stagnation areas, and major turbulences. During systolic and diastolic cycles, stagnation area increase in hearts that are properly designed. Stagnation areas may also occur in properly designed artificial hearts that are not working with a maximum stroke volume. The ellipsoid heart avoids stagnation areas and major turbulences because all the inside surfaces have an adequate washout with blood. The optimum washout of these surfaces is obtained by driving the heart with a constant maximum stroke volume. The cardiac output is regulated according to Starling's law by adjusting the frequency according to the venous return.
人工心室内血栓的形成是由生物材料的作用、血流停滞区域和主要湍流引起的。在收缩期和舒张期循环过程中，设计合理的心脏中血流停滞区域会增加。血流停滞区域也可能出现在设计合理但未以最大搏出量工作的人工心脏中。椭圆形心脏可避免血流停滞区域和主要湍流，因为其所有内表面都有足够的血液冲洗。通过以恒定的最大搏出量驱动心脏，可实现这些表面的最佳冲洗。根据斯塔林定律，通过根据静脉回流量调整频率来调节心输出量。
