Matsuda K, Hosie A M, Buckingham S D, Squire M D, Baylis H A, Sattelle D B
Babraham Institute Laboratory of Molecular Signalling, Department of Zoology, University of Cambridge, UK.
Brain Res. 1996 Nov 11;739(1-2):335-8. doi: 10.1016/s0006-8993(96)00998-5.
The actions of THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol) and ZAPA (Z-3-[(aminoiminomethyl)thio]prop-2-enoic acid) were tested on an ionotropic homo-oligomeric GABA receptor of Drosophila melanogaster. The amplitude of currents activated by THIP and ZAPA declined rapidly during agonist application and a rebound response was observed on washout. By correcting the pH shift induced by these acid salts, responses more typical of GABA agonists were seen. Less striking pH-dependence was observed in the case of GABA responses.
