Jaquish C E, Blangero J, Haffner S M, Stern M P, Maccluer J W
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Tex 78228-0147, USA.
Hum Hered. 1996 Nov-Dec;46(6):301-9. doi: 10.1159/000154368.
Dehydroepiandrosterone sulfate (DHEAS) is an adrenal steroid which has been inversely associated with development of atherosclerosis. We estimated heritability of serum DHEAS levels in 564 related Mexican Americans. We found a significant heritability for DHEAS (h2 = 0.39, p < 0.001). Measures of alcohol consumption, reproductive status, body composition, and HDL3 levels showed significant relationships with serum DHEAS levels. Sex and age were significantly associated with the mean, but not the genetic variance, of DHEAS levels. The results of this study demonstrate a significant genetic influence on steroid concentration and help to quantify the factors contributing to cardiovascular disease risk in Mexican Americans.
硫酸脱氢表雄酮（DHEAS）是一种肾上腺类固醇，它与动脉粥样硬化的发展呈负相关。我们估计了564名有亲缘关系的墨西哥裔美国人血清DHEAS水平的遗传度。我们发现DHEAS具有显著的遗传度（h2 = 0.39，p < 0.001）。酒精摄入量、生殖状况、身体成分和HDL3水平的测量结果显示与血清DHEAS水平存在显著关系。性别和年龄与DHEAS水平的均值显著相关，但与遗传方差无关。本研究结果表明遗传对类固醇浓度有显著影响，并有助于量化墨西哥裔美国人心血管疾病风险的影响因素。
