Goch J, Birgegård G, Wikström B, Backman U, Wadström J, Danielson B G
Department of Internal Medicine, University Hospital, Uppsala, Sweden.
Nephron. 1996;74(4):687-93. doi: 10.1159/000189475.
We have studied serum erythropoietin (EPO) levels during 6 years after kidney transplantation in 16 patients. There was a serum EPO peak around 50 mU/ml after 5 weeks. After 3 months the serum EPO level stabilized at around 30 mU/ml. Patients with good transplant function had significantly higher serum EPO levels and normalized their hemoglobin (Hb) after a mean of 3 months. If transplant function was good, Hb was normalized even if the serum EPO was only slightly elevated. Patients with poor transplant function had lower serum EPO and Hb levels. We concluded that a good transplant function is the key to a normal erythropoiesis and that small amounts of EPO are needed to improve Hb.
我们研究了16例肾移植患者肾移植后6年期间的血清促红细胞生成素（EPO）水平。5周后血清EPO峰值约为50 mU/ml。3个月后血清EPO水平稳定在30 mU/ml左右。移植功能良好的患者血清EPO水平显著更高，平均3个月后血红蛋白（Hb）恢复正常。如果移植功能良好，即使血清EPO仅略有升高，Hb也会恢复正常。移植功能差的患者血清EPO和Hb水平较低。我们得出结论，良好的移植功能是正常红细胞生成的关键，改善Hb需要少量EPO。
