痴呆症的发病与唐氏综合征中的载脂蛋白Eε4相关。
Onset of dementia is associated with apolipoprotein E epsilon4 in Down's syndrome.
作者信息
Schupf N, Kapell D, Lee J H, Zigman W, Canto B, Tycko B, Mayeux R
机构信息
Laboratory of Epidemiology, NYS Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA.
出版信息
Ann Neurol. 1996 Nov;40(5):799-801. doi: 10.1002/ana.410400518.
We examined the influence of apolipoprotein E (apoE) genotype on risk of dementia in 82 adults with Down's syndrome (DS). Compared with those with an apoE 3/3 genotype, the group of adults with DS with apoE 2/4, 3/4, and 4/4 genotypes were 5 times more likely to become demented (RR = 4.7; 95% CI = 1.2, 17.9). We hypothesize that the increased risk of dementia may be mediated by exacerbation of beta-amyloid deposition.
我们研究了载脂蛋白E（apoE）基因型对82名唐氏综合征（DS）成人痴呆风险的影响。与apoE 3/3基因型的成年人相比，apoE 2/4、3/4和4/4基因型的DS成年人群患痴呆的可能性高5倍（相对风险=4.7；95%置信区间=1.2，17.9）。我们推测，痴呆风险的增加可能是由β-淀粉样蛋白沉积加剧介导的。
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