Sapp M, Volpers C, Streeck R E
Institute for Medical Microbiology and Hygiene, University of Mainz, Germany.
Intervirology. 1996;39(1-2):49-53. doi: 10.1159/000150474.
Papillomavirus-like particles can be obtained by expression of the major capsid protein L1 alone or by coexpression with the minor capsid protein L2 in various systems. Virus-like particles (VPLs) and virions have very similar capsid structures. Immunization with VLPs yields antibodies neutralizing virions in vitro. Vaccination of animals with VLPs has been shown to protect against viral challenge. VLPs of human papillomavirus (HPV) are therefore the most promising vaccine candidate to prevent infections with HPVs associated with cervical cancer, the most frequent carcinoma in women worldwide.
乳头瘤病毒样颗粒可通过单独表达主要衣壳蛋白L1或在各种系统中与次要衣壳蛋白L2共表达来获得。病毒样颗粒（VLP）和病毒体具有非常相似的衣壳结构。用VLP免疫可产生在体外中和病毒体的抗体。已证明用VLP给动物接种疫苗可预防病毒攻击。因此，人乳头瘤病毒（HPV）的VLP是预防与宫颈癌相关的HPV感染的最有前景的疫苗候选物，宫颈癌是全球女性中最常见的癌症。
