Ruel P, Hanouz J L, Riou B, Lecarpentier Y, Coriat P
Départment d'Anesthésie-Réanimation, Centre Hospitalier Universitaire (CHU) Pitié-Salpêtrière, Paris, France.
Br J Anaesth. 1996 Nov;77(5):653-7. doi: 10.1093/bja/77.5.653.
Eltanolone is a new short-acting i.v. induction agent that induces less cardiovascular depression than propofol or thiopentone and has no significant effect on intrinsic contractility in normal myocardium. However, its effects on diseased myocardium are unknown. We have studied in vitro the effects of eltanolone 0.1, 1, and 10 micrograms ml-1 on the intrinsic contractility of left ventricular papillary muscles from normal hamsters and those with hypertrophic cardiomyopathy (strain BIO 14.6, 6-month-old) (Krebs-Henseleit solution, 29 degrees C, pH 7.40, Ca2+ 2.5 mmol litre-1, stimulation frequency 3 min-1). Cardiac hypertrophy (mean 134 (SD 9)%, P < 0.001) was observed in cardiomyopathic hamsters. Contractility of papillary muscles from hamsters with cardiomyopathy was less than that of controls, as shown by the lower active isometric force (8 (3) vs 35 (14) mN mm-2, P < 0.001). Eltanolone did not induce any significant inotropic or lusitropic effects in normal hamsters, and the effects of eltanolone were not significantly different between normal hamsters and those with cardiomyopathy.
依托那隆是一种新型短效静脉诱导剂，与丙泊酚或硫喷妥钠相比，它引起的心血管抑制作用较小，对正常心肌的内在收缩性无显著影响。然而，其对患病心肌的作用尚不清楚。我们在体外研究了0.1、1和10微克/毫升依托那隆对正常仓鼠以及患有肥厚型心肌病（BIO 14.6品系，6月龄）的仓鼠左心室乳头肌内在收缩性的影响（ Krebs-Henseleit溶液，29℃，pH 7.40，Ca2+ 2.5毫摩尔/升，刺激频率3次/分钟）。在患有心肌病的仓鼠中观察到心脏肥大（平均134（标准差9）%，P < 0.001）。如较低的主动等长力所示，患有心肌病的仓鼠乳头肌的收缩性低于对照组（8（3）对35（14）毫牛顿/平方毫米，P < 0.001）。依托那隆在正常仓鼠中未引起任何显著的正性肌力或变时性作用，并且在正常仓鼠和患有心肌病的仓鼠之间，依托那隆的作用没有显著差异。
