Dhundee J, Cotter M, Gibbs A R
Department of Histology and Cytology, Llandough Hospital Trust, Penarth, Cardiff, UK.
Cytopathology. 1996 Dec;7(6):406-13. doi: 10.1111/j.1365-2303.1996.tb00546.x.
Between January 1989 and May 1990, the Department of Cytology of Llandough Hospital examined 784 pleural fluid cytological preparations, 99 of which were also examined as paraffin wax sections of clots that had formed. To assess whether this practice yields worthwhile information, we reviewed the cytology and clot sections of 99 patients with pleural effusions and correlated the results with subsequent histology and review of clinical case notes. The specificities of each method separately and when combined was high: 92% clot section, 85% smear cytology and 85% combined. The sensitivity using clot section alone was 49%, smear cytology alone 46% and in combination, 54%. Analysis showed no significant difference between sensitivities. When pleural fluid clot formation occurs, we recommend the continued examination of clot sections, since it yields an increase in positive diagnoses, albeit not statistically significant.
1989年1月至1990年5月期间，兰德奥医院细胞学部门检查了784份胸水细胞学标本，其中99份标本还作为已形成凝块的石蜡切片进行了检查。为了评估这种做法是否能提供有价值的信息，我们回顾了99例胸腔积液患者的细胞学和凝块切片，并将结果与后续的组织学检查以及临床病例记录回顾进行了对比。单独使用每种方法以及联合使用时的特异性都很高：凝块切片为92%，涂片细胞学为85%，联合检查为85%。单独使用凝块切片的敏感性为49%，单独使用涂片细胞学为46%，联合使用时为54%。分析显示敏感性之间无显著差异。当胸水形成凝块时，我们建议继续检查凝块切片，因为它能增加阳性诊断率，尽管在统计学上不显著。
