Yamashita N, Oba K, Nakano H, Metori S
Division of Geriatric Medicine, Nippon Medical School.
Nihon Ronen Igakkai Zasshi. 1996 Oct;33(10):754-60. doi: 10.3143/geriatrics.33.754.
We studied age-related changes in the concentrations in serum of ferritin, glycosylated ferritin, and non-glycosylated ferritin. The concentrations were determined in 95 healthy subjects: 39 men and 56 women, aged from 22 to 94 years. In the men, age correlated significantly with serum ferritin (r = 0.332, p < 0.05) and non-glycosylated serum ferritin (r = 0.628, p < 0.001) but not with glycosylated serum ferritin. In the women, age correlated significantly with serum ferritin (r = 0.456, p < 0.001), non-glycosylated serum ferritin (r = 0.439, p < 0.001), and glycosylated serum serum ferritin (r = 0.415, p < 0.01). The ratio of glycosylated serum ferritin to serum ferritin correlated negatively with age both in men and in women (men: r = -0.661, p < 0.001; women: r = -0.411, p < 0.01). Serum non-glycosylated ferritin levels were higher in older men. Both serum glycosylated ferritin and non-glycosylated ferritin levels were higher in older women, but this phenomenon was more pronounced with respect to the non-glycosylated form. These results suggest that hyperferritinemia in the elderly is mainly caused by an increase in the concentration of non-glycosylated ferritin, both in men and in women.
我们研究了血清中铁蛋白、糖基化铁蛋白和非糖基化铁蛋白浓度的年龄相关变化。在95名健康受试者中测定了这些浓度，其中包括39名男性和56名女性，年龄在22至94岁之间。在男性中，年龄与血清铁蛋白（r = 0.332，p < 0.05）和非糖基化血清铁蛋白（r = 0.628，p < 0.001）显著相关，但与糖基化血清铁蛋白无关。在女性中，年龄与血清铁蛋白（r = 0.456，p < 0.001）、非糖基化血清铁蛋白（r = 0.439，p < 0.001）和糖基化血清铁蛋白（r = 0.415，p < 0.01）显著相关。糖基化血清铁蛋白与血清铁蛋白的比值在男性和女性中均与年龄呈负相关（男性：r = -0.661，p < 0.001；女性：r = -0.411，p < 0.01）。老年男性的血清非糖基化铁蛋白水平较高。老年女性的血清糖基化铁蛋白和非糖基化铁蛋白水平均较高，但这种现象在非糖基化形式方面更为明显。这些结果表明，老年人的高铁蛋白血症主要是由男性和女性非糖基化铁蛋白浓度的增加引起的。
