硝酸甘油可增强马蹄内一氧化氮介导的灌注。
Glyceryl trinitrate enhances nitric oxide mediated perfusion within the equine hoof.
作者信息
Hinckley K A, Fearn S, Howard B R, Henderson I W
机构信息
Department of Animal and Plant Sciences, University of Sheffield.
出版信息
J Endocrinol. 1996 Nov;151(2):R1-8. doi: 10.1677/joe.0.151r001.
Laminitis, a microvascular disease of the equine hoof leads to severe lameness. Exogenous iv 1-arginine and transdermal nitric oxide donors, such as GTN, applied to the pasterns improve lameness during acute laminitis. Near Infrared spectroscopy in an earlier study showed haemostasis and ischaemia in the hoof during acute laminitis, both were alleviated by 1-arginine. Quantitative NIRS in the present study shows that transdermal GTN increases blood flow in the equine hoof. It is concluded that glyceryl trinitrate enhances nitric oxide mediated perfusion within the equine hoof in normal and chronically laminitic horses and ponies.
蹄叶炎是马属动物蹄部的一种微血管疾病，会导致严重跛行。外源性静脉注射L-精氨酸以及经皮应用一氧化氮供体（如硝酸甘油）于马的跗关节，可改善急性蹄叶炎期间的跛行状况。早期一项研究中，近红外光谱显示急性蹄叶炎期间蹄部存在止血和缺血现象，而L-精氨酸均可缓解这两种情况。本研究中的定量近红外光谱显示，经皮应用硝酸甘油可增加马属动物蹄部的血流量。得出的结论是，硝酸甘油可增强正常马、慢性蹄叶炎马和矮种马的蹄部一氧化氮介导的灌注。
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