[沙利度胺治疗慢性多形性红斑：复发型和持续型。26例患者的回顾性研究]
[Treatment by thalidomide of chronic multiforme erythema: its recurrent and continuous variants. A retrospective study of 26 patients].
作者信息
Cherouati K, Claudy A, Souteyrand P, Cambazard F, Vaillant L, Moulin G, Crickx B, Morel P, Lamorelle A, Revuz J
机构信息
Service de Dermatologie, Hôpital Henri-Mondor, Créteil.
出版信息
Ann Dermatol Venereol. 1996;123(6-7):375-7.
INTRODUCTION
The objective of this study was to evaluate the efficacy of thalidomide in the treatment of chronic erythema multiforme unresponsive to usual treatments.
PATIENTS AND METHODS
Twenty-six patients with chronic erythema multiforme were given thalidomide 100 mg/day after other treatments had failed, particularly acyclovir and prednisone.
RESULTS
Twenty patients had recurrent erythema multiforme and were given thalidomide at the beginning of an episode. The duration of the episodes was reduced by 11 days on the average. Six of the patients had subintrant erythema multiforme and were given continuous treatment. Lesions disappeared within 5 to 8 days and remission was maintained with low dose-treatment.
DISCUSSION
The spectacular results obtained here should be verified in a controlled study.
引言
本研究的目的是评估沙利度胺对常规治疗无效的慢性多形红斑的治疗效果。
患者与方法
26例慢性多形红斑患者在其他治疗（尤其是阿昔洛韦和泼尼松）失败后，接受了每日100毫克沙利度胺的治疗。
结果
20例复发性多形红斑患者在发作开始时接受了沙利度胺治疗。发作持续时间平均缩短了11天。6例患者患有亚急性多形红斑并接受了持续治疗。皮损在5至8天内消失，低剂量治疗维持了缓解状态。
讨论
此处获得的显著结果应在对照研究中得到验证。
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