Host-tumor relationship. XXXIV. Hyaluronidase activity and hyaluronidase inhibitor in the serum of patients with malignant tumors.

Current determinations of the hyaluronidase activity and hyaluronidase inhibitor in the serum of patients with a tumor disease failed to show a correlation between a lowered hyaluronidase activity and increased inhibitor level. The serum fraction that contained the inhibitor and which had been obtained by gel filtration of Sephadex G-200 had no in vitro inhibitory effect on the serum fraction containing hyaluronidase. Hence, the decreased serum hyaluronidase activity in these patients is not due to an increased levles of hyaluronidase inhibitor.