Satoh K, Kimura K, Takimoto T, Kihira K, Taniguchi Y, Saifuku K
Department of Gastroenterology, Jichi Medical School, Tochigi, Japan.
J Gastroenterol. 1996 Nov;31 Suppl 9:53-5.
We reviewed reports on the efficacy of clarithromycin in eradicating Helicobacter pylori. Reports on dual and 1-week triple therapy that included clarithromycin were analyzed to assess the eradication rates of H. pylori infection. Dual therapy with clarithromycin and a proton pump inhibitor achieved eradication rates of 38%-83%, and 1-week triple therapy with omeprazole, clarithromycin, and other antibiotics achieved eradication rates, of 80%-96%. The incidence of side effects with all regimens was low. Clarithromycin is useful for treatment of H. pylori infection. One-week triple therapy that includes clarithromycin and a proton pump inhibitor effectively eradicates H. pylori.
我们回顾了关于克拉霉素根除幽门螺杆菌疗效的报告。分析了包含克拉霉素的双联疗法和1周三联疗法的报告，以评估幽门螺杆菌感染的根除率。克拉霉素与质子泵抑制剂的双联疗法根除率为38%-83%，奥美拉唑、克拉霉素和其他抗生素的1周三联疗法根除率为80%-96%。所有治疗方案的副作用发生率都很低。克拉霉素对幽门螺杆菌感染的治疗有用。包含克拉霉素和质子泵抑制剂的1周三联疗法能有效根除幽门螺杆菌。
