Poltorak M, Williams J R, Moore K D, Freed W J
Section on Preclinical Neuroscience, NIMH Neuroscience Center at St. Elizabeths, Washington, D.C. 20032, USA.
J Neural Transplant Plast. 1997 Jan-Mar;6(1):59-62. doi: 10.1155/NP.1997.59.
L1 antigen promotes neurite outgrowth from dopaminergic neurons in tissue culture. In the present study, we examined the effects of dopaminergic deafferentation of the striatum on L1 expression. In the medial-periventricular part of the striatum, both complete and partial substantia nigra (SN) lesions decreased L1 expression. Complete lesions increased L1 expression in the dorso-medial and ventro-lateral parts of the striatum on the lesioned side when compared with that on the non-lesioned side. The decrease in the ventro-lateral area was maintained in animals examined three months after the lesioning. Animals with partial SN lesions showed a different pattern of altered L1 expression. After frontal cortex lesions, changes in L1 expression also occur preferentially in the dorso-medial and periventricular striatum. Therefore, the results indicate a complex regulation of L1 expression after damage of striatal circuitry, manifested by a preferential occurrence of changes in periventricular regions.
L1抗原在组织培养中可促进多巴胺能神经元的轴突生长。在本研究中，我们检测了纹状体多巴胺能脱失对L1表达的影响。在纹状体的内侧脑室周部分，黑质（SN）的完全性和部分性损伤均降低了L1表达。与未损伤侧相比，完全性损伤使损伤侧纹状体背内侧和腹外侧部分的L1表达增加。损伤后3个月检查的动物中，腹外侧区域的L1表达降低仍持续存在。部分SN损伤的动物表现出不同的L1表达改变模式。额叶皮质损伤后，L1表达的变化也优先发生在背内侧和脑室周纹状体。因此，结果表明纹状体回路损伤后L1表达受到复杂调控，表现为脑室周区域优先发生变化。
