Muramatsu T, Hashimoto S, Inoue T, Shimono M, Noma H, Shigematsu T
Department of Pathology, Tokyo Dental College, Chiba, Japan.
J Oral Pathol Med. 1996 Oct;25(9):516-21. doi: 10.1111/j.1600-0714.1996.tb00308.x.
A rare case of clear cell odontogenic carcinoma was investigated using histochemical and immunohistochemical methods. The tumor occurred in the anterior mandible of a 69-year-old Japanese man. Histologically, the tumor was composed mostly of large clear cells and squamous cells. Columnar-shaped cells with basophilic nuclei polarized away from the basement membrane were observed at the periphery of the tumor foci. The tumor cells had aggressively invaded muscle and perineural tissues. The tumor cells were positive for PAS staining. Immunohistochemically, tumor cells reacted positively to keratin, cytokeratin19, epithelial membrane antigen, and S-100 protein. The tumor was diagnosed as a clear cell odontogenic carcinoma. Its characteristics are discussed in term of its histopathological, histochemical and immunohistochemical features.
采用组织化学和免疫组织化学方法对1例罕见的透明细胞牙源性癌进行了研究。该肿瘤发生于一名69岁日本男性的下颌前部。组织学上，肿瘤主要由大的透明细胞和鳞状细胞组成。在肿瘤灶周边可见核嗜碱性、柱状且远离基底膜极化的细胞。肿瘤细胞已侵袭至肌肉和神经周围组织。肿瘤细胞PAS染色阳性。免疫组织化学显示，肿瘤细胞对角蛋白、细胞角蛋白19、上皮膜抗原和S-100蛋白呈阳性反应。该肿瘤被诊断为透明细胞牙源性癌。根据其组织病理学、组织化学和免疫组织化学特征对其特点进行了讨论。
