McGuire E J, Anderson J A, Gough A W, Herman J R, Pegg D G, Theiss J C, de la Iglesia F A
Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, Ann Arbor, Michigan 48105, USA.
J Toxicol Sci. 1996 Nov;21(4):207-14. doi: 10.2131/jts.21.4_207.
Acute, subacute, and chronic toxicity studies, carcinogenicity bioassays, and reproductive and genetic toxicology studies were performed with quinapril, an ACE inhibitor used in the treatment of hypertension. Acute toxicity is minimal in rodents, and repeated dosing elicits gastric irritation, juxtaglomerular apparatus (JGA) hypertrophy and hyperplasia and tubular degenerative changes in the kidney, and reduced red cell parameters and heart weights in rodents and/or dogs. Other manifestations of toxicity, including hepatic lesions in dogs, reduced offspring weights in rats, marked sensitivity of the rabbit, and clastogenic effects at cytotoxic doses in the in vitro V79 chromosome aberration assay, have been reported with other drugs of this class.
对用于治疗高血压的血管紧张素转换酶（ACE）抑制剂喹那普利进行了急性、亚急性和慢性毒性研究、致癌生物测定以及生殖和遗传毒理学研究。喹那普利对啮齿动物的急性毒性极小，重复给药会引发啮齿动物胃部刺激、肾小球旁器（JGA）肥大和增生、肾脏肾小管退行性变化，以及啮齿动物和/或犬类的红细胞参数降低和心脏重量减轻。该类别的其他药物还出现了其他毒性表现，包括犬类肝脏损伤、大鼠后代体重减轻、兔子的显著敏感性，以及在体外V79染色体畸变试验中细胞毒性剂量下的致断裂效应。
