Herzinger T, Schirren C G, Sander C A, Jansen T, Kind P
Department of Dermatology, Ludwig-Maximilians-University of Munich, Germany.
Clin Exp Dermatol. 1996 Jul;21(4):279-82. doi: 10.1111/j.1365-2230.1996.tb00094.x.
Reactive perforating collagenosis (RPC) is a rare skin disorder characterized by reddish papules with a central keratotic plug which appear mainly on the extensor aspects of the limbs. An idiopathic or classical variant has been delineated from an acquired one which occurs in diabetes mellitus and renal failure. Histopathological examination of the lesions shows transepidermal elimination of abnormally staining bundles of collagen. To clarify the origin of this collagenous material we performed an immunohistochemical study including biopsies of two patients with RPC, one classical and one acquired. Staining reactivity to antibodies against type IV collagen was observed, thus providing evidence that the collagen eliminated in RPC may be derived from the basement membrane zone.
反应性穿通性胶原病（RPC）是一种罕见的皮肤疾病，其特征为主要出现在四肢伸侧的、带有中央角质栓的红色丘疹。特发性或经典型变体已与发生于糖尿病和肾衰竭的后天获得型相区分。病变的组织病理学检查显示，异常染色的胶原束经表皮排出。为了阐明这种胶原物质的来源，我们进行了一项免疫组织化学研究，包括对两名RPC患者（一名经典型和一名后天获得型）的活检。观察到对IV型胶原抗体的染色反应性，从而提供了证据表明RPC中排出的胶原可能来源于基底膜带。
