de Argila D, Ortiz-Romero P L, Ortiz-Frutos J, Rodriguez-Peralto J L, Iglesias L
Department of Dermatology, Hospital Universitario Doce de Octubre, Madrid, Spain.
Clin Exp Dermatol. 1996 Jul;21(4):313-4. doi: 10.1111/j.1365-2230.1996.tb00106.x.
Cutaneous amyloidosis and multiple endocrine neoplasia 2A (MEN 2A) have been previously reported in several families. A genetic linkage of both disorders has recently been described. Notalgia paraesthetica has been suggested to be involved in the aetiology of amyloidosis in such patients. We report such an association in a 48-year-old woman with several relatives suffering from MEN 2A. Treatment with topical capsaicin, which has been shown to be effective in notalgia paraesthetica, was not useful in our patient.
皮肤淀粉样变和多发性内分泌肿瘤2A（MEN 2A）此前已在多个家族中被报道。最近有研究描述了这两种疾病的遗传联系。感觉异常性背痛被认为与这类患者淀粉样变的病因有关。我们报告了一名48岁女性患者存在这种关联，她有多名亲属患有MEN 2A。外用辣椒素治疗在感觉异常性背痛中已被证明有效，但对我们的患者无效。
