苯乙肼治疗抑郁症患者。对尿中3-甲氧基-4-羟基苯乙二醇排泄量的影响及其与临床反应的关系。

Phenelzine in depressed patients. Effects on urinary MHPG excretion in relation to clinical response.

作者信息

Beckmann H, Murphy D L

出版信息

Neuropsychobiology. 1977;3(1):49-55. doi: 10.1159/000117589.

Abstract

Depressed patients' treatment with the monoamine oxidase inhibiting antidepressant, phenelzine, developed marked reductions in urinary 3-methoxy-4-hydroxyphenylglycol (MHPG) excretion. Pretreatment levels of urinary MHPG and platelet monoamine oxidase activity were significantly correlated with each other, but the magnitude of reduction in these measurements produced by phenelzine treatment did not correspond as closely. Similarly, MHPG levels were not significantly different in patients with antidepressant responses to the drug compared to nonresponders.

摘要

使用单胺氧化酶抑制性抗抑郁药苯乙肼治疗抑郁症患者时，其尿中3-甲氧基-4-羟基苯乙二醇（MHPG）排泄量显著降低。尿中MHPG的预处理水平与血小板单胺氧化酶活性显著相关，但苯乙肼治疗引起的这些测量值的降低幅度之间的对应关系并不那么紧密。同样，与无反应者相比，对该药物有抗抑郁反应的患者的MHPG水平没有显著差异。