Davey G M, Tucek-Szabo C L, Boyd R L
Department of Pathology and Immunology, Monash University Medical School, Prahran, Victoria, Australia.
Leuk Res. 1996 Oct;20(10):853-66. doi: 10.1016/0145-2126(95)00102-6.
The thymic stroma has long been implicated in AKR thymic leukaemia. In this study an extensive panel of monoclonal antibodies was used to investigate changes in the AKR thymic microenvironment, in parallel with thymocyte differentiation of normal (2 month), preleukaemic (5-7 month) and leukaemic (> 7 month) mice. We found select alterations in the thymic stroma, including a loss of isolated medullary antigens and changes in MTS 32, a mAb detecting an antigen on both thymocytes and stroma in the thymic cortex. Stromal alterations were accompanied by shifts in thymocyte differentiation and the appearance of the leukaemogenic mink cell focus-forming (MCF) murine leukaemia virus.
长期以来，胸腺基质一直被认为与AKR胸腺白血病有关。在本研究中，我们使用了大量的单克隆抗体来研究AKR胸腺微环境的变化，同时研究正常（2个月）、白血病前期（5 - 7个月）和白血病期（> 7个月）小鼠的胸腺细胞分化情况。我们发现胸腺基质存在特定改变，包括孤立的髓质抗原丧失以及MTS 32的变化，MTS 32是一种可检测胸腺皮质中胸腺细胞和基质上抗原的单克隆抗体。基质改变伴随着胸腺细胞分化的变化以及致白血病的水貂细胞集落形成（MCF）鼠白血病病毒的出现。
