环氧丙烷与环氧乙烷共聚物类表面活性剂。第十一部分。单甲氧基聚（乙二醇）（M-PEG）胶束对乙酰水杨酸（ASA）的增溶作用。
Tensides from the group of propylene oxide and ethylene oxide copolymers. Part XI. Solubilization of acetylsalicylic acid (ASA) by monomethoxypoly(ethylene glycol) (M-PEG) micelles.
作者信息
Zgoda M M
机构信息
Department of Applied Pharmacy, Faculty of Pharmacy, School of Medicine, Lódź, Poland.
出版信息
Acta Pol Pharm. 1995 Jan-Feb;52(1):61-5.
The process of structural solubilization of acetyl salicylic acid (ASA) in a balanced system (weight-balanced) by micelles of monomethoxypoly(ethylene glycol)-s-CH3OCH2[CH2OCH2]n-CH2OH (M(r) = 350-5000) types and, for comparison, by those of F-68 and F-108 Pluronics, was investigated. The determined viscosity and hydrodynamic parameters ([eta], KH, M eta, Robs, omega) allowed for the calculation of solubilizing activity of monomethoxypoly(ethylene glycol) micelles-pi s(ASA). The results of the investigation point at monomethoxypoly(ethylene glycol)s as an excipient, which may help to obtain new drug delivery systems.
研究了在平衡体系（重量平衡）中，单甲氧基聚（乙二醇）-s-CH3OCH2[CH2OCH2]n-CH2OH（M(r)=350-5000）型胶束以及作为对照的F-68和F-108普朗尼克胶束对乙酰水杨酸（ASA）的结构增溶过程。所测定的粘度和流体动力学参数（[η]、KH、M η、Robs、ω）可用于计算单甲氧基聚（乙二醇）胶束对ASA的增溶活性——πs(ASA)。研究结果表明单甲氧基聚（乙二醇）可作为一种辅料，有助于获得新型药物递送系统。
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