The influence of selected general anesthetics on pharmacokinetic parameters of some antiarrhythmic drugs in rabbits. Part IV. Lidocaine.

The influence of selected general anesthetics: thiopental, propofol, ketamine and pentobarbital on the lidocaine pharmacokinetic parameters was studied in rabbits. Thiopental, ketamine and propofol caused a decrease of lidocaine blood level, but pentobarbital caused its increase. Pentobarbital, thiopental and ketamine caused an increase of lidocaine distribution rate constant, a decrease of its elimination rate constant, and prolongation of biological half-life. These anesthetics caused also an increase of volume of distribution and mean residence time of lidocaine. The anesthesia with propofol resulted in the increase of lidocaine volume of distribution and clearance.